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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Fernblock® XP
Drug Type Not Available
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 905
Ref_1
Pair Name Sulforaphane, Fernblock® XP
Partner Name Sulforaphane
Disease Info [ICD-11: 2C30] Melanoma Investigative
Biological Phenomena Inhibition-->Cell metastasis
Gene Regulation Down-regulation Expression IL1B hsa3553
Down-regulation Expression MMP1 hsa4312
Down-regulation Expression MMP3 hsa4314
In Vitro Model WM115 Melanoma Homo sapiens (Human) CVCL_0040
WM266-4 Melanoma Homo sapiens (Human) CVCL_2765
Result SFN/FB was more efficient than SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1β secretion in the presence of a pro-inflammatory stimulus such as TNF-α. The potential use of SFN/FB based supplements for the prevention of skin aging and as adjuvants in the treatment of advanced melanoma is suggested.
03. Reference
No. Title Href
1 The Combination of Sulforaphane and Fernblock® XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines. Nutrients. 2020 May 30;12(6):1608. doi: 10.3390/nu12061608. Click
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